Week 13’s biggest matchup is a rematch of last year’s NFC Championship Game: The Philadelphia Eagles opened as 1-point favorites over the visiting San Francisco 49ers, but the line has already moved quickly.
In the other 12 games, some big favorites will be looking to shine in the prime-time spotlight, beginning with the Dallas Cowboys hosting the Seattle Seahawks on Thursday night. On Sunday night, the Kansas City Chiefs visit the Green Bay Packers for Patrick Mahomes‘ first foray at Lambeau Field. The week’s finale will see the Cincinnati Bengals limp into a matchup with the Jacksonville Jaguars for “Monday Night Football” on ABC and ESPN.
We’ve got lines for every matchup, updated throughout the week.
Favorites are selected by ESPN’s Football Power Index (FPI). Odds by ESPN BET.
Seattle Seahawks @ Dallas Cowboys -8
AT&T Stadium, Arlington, Texas
Thursday 8:15 p.m. ET
Money Line: Seattle Seahawks (+320); Dallas Cowboys (-400)
Total: 46.5 (second highest of the week)
FPI favorite: Cowboys by 11 (79.5% to win outright)
Indianapolis Colts -2.5 @ Tennessee Titans
Nissan Stadium, Nashville, Tennessee
Sunday 1 p.m. ET
Money Line: Indianapolis Colts (-130); Tennessee Titans (+110)
Total: 42.5 (sixth highest of the week)
FPI favorite: Colts by 2.5 (57.3% to win outright)
Los Angeles Chargers -6 @ New England Patriots
Gillette Stadium, Foxborough, Massachusetts
Sunday 1 p.m. ET
Money Line: Los Angeles Chargers (-250); New England Patriots (+210)
Total: 41.5 (eighth highest of the week)
FPI favorite: Chargers by 5.5 (66.1% to win outright)
Detroit Lions -3.5 @ New Orleans Saints
Caesars Superdome, New Orleans
Sunday 1 p.m. ET
Money Line: Detroit Lions (-195); New Orleans Saints (+165)
Total: 45.5 (fourth highest of the week)
FPI favorite: Lions by 2.1 (56.2% to win outright)
Atlanta Falcons -3 @ New York Jets
MetLife Stadium, East Rutherford, New Jersey
Sunday 1 p.m. ET
Money Line: Atlanta Falcons (-145); New York Jets (+125)
Total: 34.5 (13th highest of the week)
FPI favorite: Falcons by 2.4 (57% to win outright)
Arizona Cardinals @ Pittsburgh Steelers -5.5
Acrisure Stadium, Pittsburgh
Sunday 1 p.m. ET
Money Line: Arizona Cardinals (+210); Pittsburgh Steelers (-250)
Total: 39.5 (10th highest of the week)
FPI favorite: Steelers by 7.8 (72% to win outright)
Carolina Panthers @ Tampa Bay Buccaneers -6
Raymond James Stadium, Tampa, Florida
Sunday 1 p.m. ET
Money Line: Carolina Panthers (+220); Tampa Bay Buccaneers (-270)
Total: 38.5 (11th highest of the week)
FPI favorite: Buccaneers by 7.5 (71.4% to win outright)
Miami Dolphins -9.5 @ Washington Commanders
FedExField, Landover, Maryland
Sunday 1 p.m. ET
Money Line: Miami Dolphins (-450); Washington Commanders (+360)
Total: 49.5 (highest of the week)
FPI favorite: Dolphins by 11.4 (80.4% to win outright)
Denver Broncos @ Houston Texans -3
NRG Stadium, Houston
Sunday 4:05 p.m. ET
Money Line: Denver Broncos (+130); Houston Texans (-150)
Total: 45.5 (fourth highest of the week)
FPI favorite: Texans by 1.5 (54.5% to win outright)
Cleveland Browns @ Los Angeles Rams -4.5
SoFi Stadium, Inglewood, California
Sunday 4:25 p.m. ET
Money Line: Cleveland Browns (+175); Los Angeles Rams (-210)
Total: 38.5 (11th highest of the week)
FPI favorite: Rams by 4.8 (64% to win outright)
San Francisco 49ers -2.5 @ Philadelphia Eagles
Lincoln Financial Field, Philadelphia
Sunday 4:25 p.m. ET
Money Line: San Francisco 49ers (-140); Philadelphia Eagles (+120)
Total: 46.5 (second highest of the week)
FPI favorite: 49ers by 2 (55.8% to win outright)
Kansas City Chiefs -7 @ Green Bay Packers
Lambeau Field, Green Bay, Wisconsin
Sunday 8:20 p.m. ET
Money Line: Kansas City Chiefs (-300); Green Bay Packers (+250)
Total: 42.5 (sixth highest of the week)
FPI favorite: Chiefs by 7.6 (71.7% to win outright)
Cincinnati Bengals @ Jacksonville Jaguars -8
TIAA Bank Field, Jacksonville, Florida
Monday 8:15 p.m. ET
Money Line: Cincinnati Bengals (+300); Jacksonville Jaguars (-380)
Total: 40.5 (ninth highest of the week)
FPI favorite: Jaguars by 5.8 (66.8% to win outright)
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