2025 NFL odds Week 1: Lines, spreads for all 16 games

The NFL season is nearly upon us.

The 2025-26 NFL schedule has officially been released, meaning it’s time to start placing wagers.

The Super-Bowl-champion Philadelphia Eagles will kick off the 2025 season by hosting their NFC East rivals, the Dallas Cowboys, on Sept. 4.

With a loaded Week 1 slate, let’s check out the lines for each game at DraftKings Sportsbook as of May 15.

(All times ET)

2024 NFL Week 1 Odds and Predictions

THURSDAY, SEPT. 4

COWBOYS @ EAGLES (8:20 p.m., NBC)

Point spread: Eagles -7 (Eagles favored to win by 7 points or more, otherwise Cowboys cover)
Moneyline: Eagles -310 favorites to win (bet $10 to win $13.23 total); Cowboys +250 underdogs to win (bet $10 to win $35 total)
Total scoring Over/Under: 46.5 points scored by both teams combined

FRIDAY, SEPT. 5

CHIEFS @ CHARGERS (8:15 p.m., YouTube)

Point spread: Chiefs -3 (Chiefs favored to win by 3 points or more, otherwise Chargers cover)
Moneyline: Chiefs -155 favorites to win (bet $10 to win $16.45 total); Chargers +130 underdogs to win (bet $10 to win $23 total)
Total Over/Under: 44.5 points scored by both teams combined

SUNDAY, SEPT. 7

RAIDERS @ PATRIOTS (1 p.m., CBS)

Point spread: Patriots -3.5 (Patriots favored to win by 4 points or more, otherwise Raiders cover)
Moneyline: Patriots -166 favorites to win (bet $10 to win $16.02 total); Raiders +140 underdogs to win (bet $10 to win $24 total)
Total Over/Under: 43.5 points scored by both teams combined

STEELERS @ JETS (1 p.m., CBS)

Point spread: Steelers -2.5 (Steelers favored to win by 3 points or more, otherwise Jets cover)
Moneyline: Steelers -142 favorites to win (bet $10 to win $17.04 total); Jets +120 underdogs to win (bet $10 to win $22 total)
Total Over/Under: 39.5 points scored by both teams combined

DOLPHINS @ COLTS (1 p.m., CBS)

Point spread: Colts -1.5 (Colts favored to win by 2 points or more, otherwise Dolphins cover)
Moneyline: Colts -120 favorites to win (bet $10 to win $18.33 total); Dolphins +100 underdogs to win (bet $10 to win $20 total)
Total Over/Under: 45.5 points scored by both teams combined

CARDINALS @ SAINTS (1 p.m., CBS)

Point spread: Cardinals -3.5 (Cardinals favored to win by 4 points or more, otherwise Saints cover)
Moneyline: Cardinals -192 favorites to win (bet $10 to win $15.21 total); Saints +160 underdogs to win (bet $10 to win $26 total)
Total Over/Under: 43.5 points scored by both teams combined

GIANTS @ COMMANDERS (1 p.m., FOX and FOX Sports app)

Point spread: Commanders -7.5 (Commanders favored to win by 8 points or more, otherwise Giants cover)
Moneyline: Commanders -340 favorites to win (bet $10 to win $12.94 total); Giants +270 underdogs to win (bet $10 to win $37 total)
Total Over/Under: 45.5 points scored by both teams combined

PANTHERS @ JAGUARS (1 p.m., FOX and FOX Sports app)

Point spread: Jaguars -3.5 (Jaguars favored to win by 4 points or more, otherwise Panthers cover)
Moneyline: Jaguars -166 favorites to win (bet $10 to win $16.02 total) Panthers +140 underdogs to win (bet $10 to win $24 total)
Total Over/Under: 45.5 points scored by both teams combined

BENGALS @ BROWNS (1 p.m., FOX and FOX Sports app)

Point spread: Bengals -4.5 (Bengals favored to win by 5 points or more, otherwise Browns cover)
Moneyline: Bengals -218 favorites to win (bet $10 to win $14.59 total); Browns +180 underdogs to win (bet $10 to win $28 total)
Total Over/Under: 44.5 points scored by both teams combined

BUCCANEERS @ FALCONS (1 p.m., FOX and FOX Sports app)

Point spread: Buccaneers -2.5 (Buccaneers favored to win by 3 points or more, otherwise Falcons cover)
Moneyline: Buccaneers -142 favorites to win (bet $10 to win $17.04 total); Falcons +120 underdogs to win (bet $10 to win $22 total)
Total Over/Under: 47.5 points scored by both teams combined

TITANS @ BRONCOS (4:05 p.m., FOX and FOX Sports app)

Point spread: Broncos -7.5 (Broncos favored to win by 8 points or more, otherwise Titans cover)
Moneyline: Broncos -375 favorites to win (bet $10 to win $12.67 total); Titans +295 underdogs to win (bet $10 to win $39.50 total)
Total Over/Under: 43.5 points scored by both teams combined

49ERS @ SEAHAWKS (4:05 p.m., FOX and FOX Sports app)

Point spread: 49ers -1.5 (49ers favored to win by 2 points or more, otherwise Seahawks cover)
Moneyline: 49ers -120 favorites to win (bet $10 to win $18.33 total); Seahawks +100 underdogs to win (bet $10 to win $20 total)
Total Over/Under: 45.5 points scored by both teams combined

LIONS @ PACKERS (4:25 p.m., CBS)

Point spread: Packers -1.5 (Packers favored to win by 2 points or more, otherwise Lions cover)
Moneyline: Packers -118 favorites to win (bet $10 to win $18.47 total); Lions -102 underdogs to win (bet $10 to win $19.80 total)
Total Over/Under: 48.5 points scored by both teams combined

TEXANS @ RAMS (4:25 p.m., CBS)

Point spread: Rams -3.5 (Rams favored to win by 4 points or more, otherwise Texans cover)
Moneyline: Rams -175 favorites to win (bet $10 to win $15.71 total); Texans +145 underdogs to win (bet $10 to win $24.50 total)
Total Over/Under: 44.5 points scored by both teams combined

RAVENS @ BILLS (8:20 p.m., NBC)

Point spread: Bills -1.5 (Bills favored to win by 2 points or more, otherwise Ravens cover)
Moneyline: Bills -122 favorites to win (bet $10 to win $18.20 total); Ravens +102 underdogs to win (bet $10 to win $20.20 total)
Total Over/Under: 51.5 points scored by both teams combined

MONDAY, SEPT. 8

VIKINGS @ BEARS (8:15 p.m., ESPN)

Point spread: Bears -1.5 (Bears favored to win by 2 points or more, otherwise Vikings cover)
Moneyline: Bears -122 favorites to win (bet $10 to win $18.20 total); Vikings +102 underdogs to win (bet $10 to win $20.20 total)
Total Over/Under: 45.5 points scored by both teams combined

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