2025 NFL Odds Week 2: Lines, Spreads for all 16 Games

After months of waiting, the first full Sunday of NFL football did not disappoint.

And with that, Week 2 kicks off Thursday night, as the Green Bay Packers host the Washington Commanders.

Here are the lines for every Week 2 matchup at DraftKings Sportsbook as of Sept. 8.

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(All times ET)

2025 NFL Week 1 Odds

THURSDAY, SEPT. 11

COMMANDERS @ PACKERS (8:15 p.m., Prime Video)

Point spread: Packers -3.5 (Packers favored to win by 3.5 points or more, otherwise Commanders cover)
Moneyline: Packers -185 favorites to win (bet $10 to win $15.41 total); Commanders +154 underdogs to win (bet $10 to win $25.40 total)
Total Over/Under: 48.5 points scored by both teams combined

SUNDAY, SEPT. 14

JAGUARS @ BENGALS (1 p.m., CBS)

Point spread: Bengals -3.5 (Bengals favored to win by 3.5 points or more, otherwise Jaguars cover)
Moneyline: Bengals -180 favorites to win (bet $10 to win $15.56 total); Jaguars +150 underdogs to win (bet $10 to win $25 total)
Total Over/Under: 50.5 points scored by both teams combined

GIANTS @ COWBOYS (1 p.m., FOX)

Point spread: Cowboys -6 (Cowboys favored to win by 6 points or more, otherwise Giants cover)
Moneyline: Cowboys -245 favorites to win (bet $10 to win $14.08 total); Giants +200 underdogs to win (bet $10 to win $30 total)
Total Over/Under: 44.5 points scored by both teams combined

BEARS @ LIONS (1 p.m., FOX)

Point spread: Lions -5.5 (Lions favored to win by 5.5 points or more, otherwise Bears cover)
Moneyline: Lions -230 favorites to win (bet $10 to win $14.35 total); Bears +190 underdogs to win (bet $10 to win $29 total)
Total Over/Under: 47.5 points scored by both teams combined

RAMS @ TITANS (1 p.m., CBS)

Point spread: Rams -6 (Rams favored to win by 6 points or more, otherwise Titans cover)
Moneyline: Rams -245 favorites to win (bet $10 to win $14.08 total); Titans +200 underdogs to win (bet $10 to win $30 total)
Total Over/Under: 41.5 points scored by both teams combined

PATRIOTS @ DOLPHINS (1 p.m., CBS)

Point spread: Dolphins -1.5 (Dolphins favored to win by 1.5 points or more, otherwise Patriots cover)
Moneyline: Dolphins -130 favorites to win (bet $10 to win $17.69 total); Patriots +110 underdogs to win (bet $10 to win $21 total)
Total Over/Under: 44.5 points scored by both teams combined

49ERS @ SAINTS (1 p.m., FOX)

Point spread: 49ers -6.5 (49ers favored to win by 6.5 points or more, otherwise Saints cover)
Moneyline: 49ers -270 favorites to win (bet $10 to win $13.70 total); Saints +220 underdogs to win (bet $10 to win $32 total)
Total Over/Under: 43.5 points scored by both teams combined

BILLS @ JETS (1 p.m., CBS)

Point spread: Bills -6.5 (Bills favored to win by 6.5 points or more, otherwise Jets cover)
Moneyline: Bills -305 favorites to win (bet $10 to win $13.28 total); Jets +245 underdogs to win (bet $10 to win $24.50 total)
Total Over/Under: 45.5 points scored by both teams combined

SEAHAWKS @ STEELERS (1 p.m., FOX)

Point spread: Steelers -2.5 (Steelers favored to win by 2.5 points or more, otherwise Seahawks cover)
Moneyline: Steelers -155 favorites to win (bet $10 to win $16.45 total); Seahawks +130 underdogs to win (bet $10 to win $23 total)
Total Over/Under: 40.5 points scored by both teams combined

BROWNS @ RAVENS (1 p.m., CBS)

Point spread: Ravens -11.5 (Ravens favored to win by 11.5 points or more, otherwise Browns cover)
Moneyline: Ravens-650 favorites to win (bet $10 to win $11.54 total); Browns +470 underdogs to win (bet $10 to win $57 total)
Total Over/Under: 45.5 points scored by both teams combined

BRONCOS @ COLTS (4:05 p.m., CBS)

Point spread: Broncos -2.5 (Broncos favored to win by 2.5 points or more, otherwise Colts cover)
Moneyline: Broncos -135 favorites to win (bet $10 to win $17.41 total); Colts +114 underdogs to win (bet $10 to win $21.40 total)
Total Over/Under: 42.5 points scored by both teams combined

PANTHERS @ CARDINALS (4:05 p.m., CBS)

Point spread: Cardinals -6.5 (Cardinals favored to win by 6.5 points or more, otherwise Panthers cover)
Moneyline: Cardinals -278 favorites to win (bet $10 to win $13.60 total); Panthers +225 underdogs to win (bet $10 to win $32.50 total)
Total Over/Under: 45.5 points scored by both teams combined

EAGLES @ CHIEFS (4:25 p.m., FOX)

Point spread: Eagles -0.5 (Eagles favored to win by 0.5 points or more, otherwise Chiefs cover)
Moneyline: Eagles -115 favorites to win (bet $10 to win $18.70 total); Chiefs -105 underdogs to win (bet $10 to win $19.52 total)
Total Over/Under: 47.5 points scored by both teams combined

FALCONS @ VIKINGS (8:20 p.m., NBC)

Point spread: Vikings -4.5 (Vikings favored to win by 4.5 points or more, otherwise Falcons cover)
Moneyline: Vikings -225 favorites to win (bet $10 to win $14.44 total); Falcons +185 underdogs to win (bet $10 to win $28.50 total)
Total Over/Under: 45.5 points scored by both teams combined

MONDAY, SEPT 15

BUCCANEERS @ TEXANS (7 p.m., ABC/ESPN)

Point spread: Texans -3 (Texans favored to win by 3 points or more, otherwise Buccaneers cover)
Moneyline: Texans -148 favorites to win (bet $10 to win $16.76 total); Buccaneers +124 underdogs to win (bet $10 to win $22.40 total)
Total Over/Under: 42.5 points scored by both teams combined

CHARGERS @ RAIDERS (10 p.m., ESPN)

Point spread: Chargers -3.5 (Chargers favored to win by 3.5 points or more, otherwise Raiders cover)
Moneyline: Chargers -185 favorites to win (bet $10 to win $15.41 total); Raiders +154 underdogs to win (bet $10 to win $25.40 total)
Total Over/Under: 46.5 points scored by both teams combined

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