Philadelphia’s Saquon Barkley’s record-breaking season in 2024-25 earned him NFL Offensive Player of the Year honors.
But that was last season.
Could the Philly star be upended at the conclusion of this NFL campaign?
Let’s check out the odds at DraftKings Sportsbook as of Nov. 4, as well as what to know about each leading candidate.
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2025-26 Offensive Player of the Year
Jonathan Taylor, RB, Colts: -135
What to know: After Week 9, Taylor’s odds moved from -225 to -135, making him the heavy favorite to win OPOY. The Colts’ workhorse running back has helped the team reach their surprising 7-2 record. His 895 yards on the ground are a league-best, as are his 12 touchdowns. On Sunday, however, he had his least-productive game of the season, rushing for 45 yards on 14 carries in Indy’s second loss of the season.
Jaxon Smith-Njigba, WR, Seahawks: +350
What to know: Smith-Njigba leads the NFL in receiving yards with 948, and the 6-2 Seahawks still have nine games to go. He’s projected to record 2,015 receiving yards, which would be an NFL record. He has four straight 100-yard receiving games, including 129 yards in a Week 9 win at Washington.
Christian McCaffrey, RB, 49ers: +600
What to know: It’s business as usual for dual-threat back McCaffrey. He has 168 carries (first), 596 rushing yards (ninth) and 626 receiving yards (seventh) for the 6-3 49ers. In a Week 9 win over the Giants, he had 106 rushing yards and a score, and 67 receiving yards and a score.
Puka Nacua, WR, Rams: +850
What to know: Nacua is tied for the second-most receptions in the NFL (61) and has the fourth-most receiving yards this season (711) despite missing a game due to injury.
Ja’Marr Chase, WR, Bengals: +1500
What to know: Chase’s 76 receptions are best in the NFL and his 831 receiving yards are good for second. In Cincy’s Week 9 loss to the Bears, he had eight catches for 111 yards. And keep in mind — he’s doing all of this without Joe Burrow.
Bijan Robinson, RB, Falcons: +2800
What to know: Robinson has 595 rushing yards and 463 receiving yards so far this season — a true dual-threat back. However, he hasn’t had a 100-yard rushing game or receiving game since Week 6.
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