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BigPaulSports > Blog > Game Analysis > 2025 NFL DPOY Odds: Myles Garrett Heavier Favorite after Week 12
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2025 NFL DPOY Odds: Myles Garrett Heavier Favorite after Week 12

BigP
Last updated: 2025/11/25 at 5:20 PM
BigP Published November 25, 2025
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2025 NFL DPOY Odds: Myles Garrett Heavier Favorite after Week 12
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Defense wins championships, and great defenders win awards.

Last year, a defensive back won NFL Defensive Player of the Year for the second time in 14 years — Denver’s Pat Surtain II.

Let’s take a look at the odds for this year’s Defensive Player of the Year at DraftKings Sportsbook as of Nov. 25, as well as what to know.

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

2025-26 NFL Defensive Player of the Year 

Myles Garrett, DE, Browns: -1000

What to know: Cleveland is 3-8, but it doesn’t matter because Garrett is just that good. His odds shifted to -1000 from -280 over the past week. In the Browns’ Week 12 win over the Raiders, Garrett recorded three sacks and four tackles for loss. 

Micah Parsons, LB/DE, Packers: +800

What to know: In the Packers’ Week 12 win over the Vikings, Parsons had two sacks and two solo tackles. While his 10 sacks on the season are fifth-best in the league, his odds in this spot over the last week have lengthened to +800 from +450.

Will Anderson Jr., DE, Texans: +1000

What to know: In the Texans’ last five games, Anderson has 6.5 sacks and seven tackles for loss. Through 12 weeks, Houston has the best defense in the NFL.

Nik Bonitto, DE, Broncos: +2500

What to know: Bonitto has 9.5 sacks on the season and 21 QB hits. Denver has won eight games in a row and has the third-best defense in the NFL.

Brian Burns, LB, Giants: +3000

What to know: Brian Burns’ 13 sacks on the season are second in the NFL. On the season, he’s got 34 solo tackles for the 2-10 Giants.

Aidan Hutchinson, DE, Lions: +3500

What to know: Over the summer, Hutchinson opened as the favorite to be named DPOY, and now he’s sixth on this list. He has just 2.5 sacks in the Lions’ last four games. 

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BigP November 25, 2025
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