Philadelphia’s Saquon Barkley’s record-breaking season in 2024-25 earned him NFL Offensive Player of the Year honors.
But that was last season.
Let’s check out the odds at DraftKings Sportsbook as of Nov. 25, as well as what to know about the candidates that are in the mix.
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2025-26 Offensive Player of the Year
Jonathan Taylor, RB, Colts: -135
What to know: Will anyone catch Taylor in this race? His odds had gotten as short as -370 but have now moved back to -135 over the last week. The Colts’ workhorse running back has helped the team reach their surprising 8-3 record. His 1,197 yards on the ground are a league-best, as are his 15 touchdowns. In a dynamic Week 10 performance, he rushed for 244 yards and three TDs, as Indianapolis defeated the Falcons 31-25 in overtime. In Week 12, he only had 58 yards on the ground and his odds lengthened.
Jaxon Smith-Njigba, WR, Seahawks: +105
What to know: Smith-Njigba leads the NFL in receiving yards with 1,313 for the 8-3 Seahawks. He has eight games this season where he racked up at least 100 yards, including 167 yards in a 30-24 win over Tennessee in Week 12. And with that, he’s closing in on Taylor, as Smith-Njigba’s odds have shortened to +105 from +255.
Christian McCaffrey, RB, 49ers: +2500
What to know: It’s business as usual for dual-threat back McCaffrey. He has 217 carries (first), 796 rushing yards and 785 receiving yards for the 8-4 49ers. In San Francisco’s Week 12, 20-9 win over the Panthers, McCaffrey had 89 rushing yards and 53 receiving yards.
Jahmyr Gibbs, RB, Lions: +3000
What to know: Gibbs has been a force for Detroit this season, rushing for 951 yards (third) and 10 TDs (T-third). In Week 12, he rushed for 219 yards and two TDs on the ground, along with 45 receiving yards and one receiving TD in the Lions’ 34-27 OT win over the Giants.
Drake Maye, QB, Patriots: +10000
What to know: While Drake Maye’s OPOY odds are on the longer side, he’s been productive enough this season for him to be firmly in the MVP conversation. As the quarterback for the 10-2 Pats, he has 3,130 passing yards and 21 TDs on the season.
Puka Nacua, WR, Rams: +10000
What to know: Nacua’s 80 receptions are tied for second in the NFL and also has the third-most receiving yards this season (947) despite missing time due to injury.
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