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The Arizona Cardinals will be the first team to debut their NFL Rivalry uniforms in this week’s Thursday Night Football game. They face the Seattle Seahawks. Both teams go into Week 4 at 2-1, but have different outlooks on their season after Week 3.
The Seahawks are coming off a 44-poont performance in their blowout win against the New Orleans Saints, while the Cardinals not only suffered their first loss, but lost running back James Conner for the year after a leg injury.
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Last 6 Meetings
- Seattle @ Arizona, 30-18 Seattle won.
- Arizona @ Seattle, 6-16 Seattle won.
- Seattle @ Arizona, 21-20 Seattle won.
- Arizona @ Seattle, 10-20 Seattle won
- Seattle @ Arizona, 31-21 Seattle won.
- Arizona @ Seahawks, 9-19, Seattle won.
Seattle Betting Info
- Seattle has covered the spread twice in 2025.
- The Seahawks have been favored by 1.5 points or more once this season, and covered the spread.
- Seattle games this year have hit the over on two of three set point totals (66.7%).
- The Seahawks have been moneyline favorites a single other time this season, a game they won.
- The implied probability for this matchup, considering the moneyline, gives the Seahawks a 55.6% chance to win.
Seattle’s Key Players
Offense
- Sam Darnold has 663 passing yards through three games this year, averaging 221.0 per game with a 70.3% completion percentage and four touchdowns against two interceptions.
- Kenneth Walker III has racked up 163 rushing yards with three touchdowns (54.3 yards per game across three games). His 4.2 yards per attempt rank 17th in the league.
- In three games played, Jaxon Smith-Njigba is averaging 107.7 yards and 7.3 receptions per game on the way to 323 receiving yards (second in the NFL) and 22 catches (fifth in the NFL). He’s been targeted 29 times, and has one receiving touchdown.
- Tory Horton averages 1.7 receptions and 21.3 yards per game, and has 64 total receiving yards and five catches. He’s gotten eight total targets, and has caught two touchdown passes (seventh in the NFL).
Defense
- On defense, Ernest Jones has 25 tackles, 2.0 TFL, and one interception in 2025.
- Byron Murphy has 14 tackles, 2.0 TFL, and 2.5 sacks this season.
- This season, Josh Jobe has recorded 17 tackles and one interception.
- Leonard Williams has 1.0 sack (second on the Seahawks) in addition to his 1.0 TFL and 15 tackles on the year.
Arizona Betting Info
- Arizona has put together a record of 2-1-0 against the spread this season.
- The Cardinals have been underdogs by 1.5 points or more once this year and covered the spread.
- Games involving Arizona have hit the over once this year.
- The Cardinals lost the only game they’ve played as the underdog this season.
- The moneyline for this contest implies a 48.8% chance of a victory for the Cardinals.
Arizona’s Key Players
Offense
- Kyler Murray has thrown for 542 yards this year, with four touchdowns and one interception. He is completing 67.4% of his attempts while averaging 180.7 yards per game and 6.1 per attempt.
- On the ground, Murray has added 107 rushing yards (second on the Cardinals).
- Trey McBride has 17 catches for 182 yards and one receiving touchdown. He has been targeted 24 times and averages 5.7 receptions per game in three games played.
- Marvin Harrison Jr. has registered 142 receiving yards and one touchdown on 10 receptions, while being targeted 17 times on the season.
- Trey Benson is scoreless on the ground, but has rushed for 125 total yards (6.0 per attempt and 41.7 per game).
- Benson has also caught eight passes for 45 yards (fourth on the Cardinals). He’s been targeted 11 times and averages 15.0 yards per game.
Defense
- In 2025, Mack Wilson has amassed 28 tackles and 2.0 TFL through three games.
- Calais Campbell has 2.0 sacks (first on the Cardinals) to go with 2.0 TFL and 11 tackles.
- During the 2025 season, Josh Sweat has six tackles, 3.0 TFL, and two sacks in three games.
- Budda Baker has 24 tackles, 1.0 TFL, and one pass defended.
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